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KMID : 1134820160450111595
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Journal of the Korean Society of Food Science and Nutrition
2016 Volume.45 No. 11 p.1595 ~ p.1603
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Anti-Inflammatory Effects of Oenanthe javanica Ethanol Extract and Its Fraction on LPS-Induced Inflammation Response
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Jang Ji-Hun
Cho Hyun-Woo
Lee Bo-Young
Yu Kang-Yeol
Yoon Ji-Young
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Abstract
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The present study examined the anti-inflammatory effects of Oenanthe javanica ethanol extract (OJE) and its fraction on the lipopolysaccharide (LPS)-induced inflammatory response in RAW 264.7 macrophage cells. OJE remarkably reduced protein expression of inducible nitric oxide (iNOS) and cyclooxygenase-2 (COX-2), resulting in inhibition of production of nitric oxide (NO). In order to identify the anti-inflammatory effects of bioactive fractions, OJE was fractionated into hexane, dichloromethane, ethyl acetate, and n-butanol fractions. The results show that the ethyl acetate and dichloromethane fractions reduced production of NO without cytotoxicity. Especially, the ethyl acetate fraction effectively reduced protein expression of iNOS and COX-2. Proinflammatory cytokine production was also reduced by ethyl acetate fractions in LPS-induced RAW 264.7 cells. These data suggest that OJE and its fraction possess pharmacological activity and might be useful for development of anti-inflammatory agents or dietary supplements.
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KEYWORD
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Oenanthe javanica, anti-inflammatory, nitric oxide
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